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第15回 日本脳低温療法学会 特別講演のご報告

座長先月7月6日(金)‐7日(土)、北里大学救命救急医学准教授・北原孝雄会長の下、横浜シンポジアにて、第15回日本脳低温療法学会が開催され、弊社は特別講演「Current status and prospects of therapeutic hypothermia for severe head injury and cerebrovascular disease」 座長:相引 眞幸先生 (愛媛大学大学院医学系研究科教授 救急侵襲制御医学講座) 演者:Kees Polderman先生 (米国ピッツバーグ大学神経集中治療部部長、客員教授) を後援させていただきました。


2010年のILCOR勧告による「心肺蘇生と救急心血管治療のためのガイドライン」改定で、心停止蘇生後脳症や新生児仮死後の低酸素性虚血性脳症に対し、低体温療法は強く推奨されるようになりましたが、頭部外傷や脳卒中に対しての低体温療法は期待されているもののエビデンスに乏しいため、Polderman先生に現状と展望を話していただきました。


poldermanPolderman先生は、2009年2月の第36回日本集中治療医学会(大阪)の弊社共催イブニングセミナー以来、2度目の来日で、現在、ヨーロッパ、米国で最も精力的に低体温療法の研究をされているドクターの一人です。
因みにPolderman先生は、現在、低体温療法に関する3つのRCTを並行して行っており、弊社が昨年9月の第4回国際低体温シンポジウムにて招聘した英国エジンバラ大学Peter Andrews教授がとりまとめを行っているEurotherm Trialにも参画されています。DVD

 

 

今回の講演内容も収録を行いましたので、DVDを御希望の方は、下記宛、お申し込みください。
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今後、頭部外傷、脳卒中への低体温療法の治療効果のエビデンスが示され、多くの患者様が良好な予後が得られるよう、弊社も情報提供に努めてまいりますので、今後ともお引き立てのほど、宜しくお願いします。

 

文責:OR/CC部 津賀茂雄

 

参考:Polderman先生の主な論文など(2004年以降)
Polderman KH, Andrews PJ. Hypothermia in patients with brain injury: the way forward? Lancet Neurology 2011; 10:404-5.

 

Polderman KH. Hypothermia, immune suppression and SDD: can we have our cake and eat it? Critical Care 2011;15:144.

 

Andrews PJ, Sinclair HL, Battison CG, Polderman KH, Citerio G, Mascia L, Harris BA, Murray GD, Stocchetti N, Menon DK, Shakur H, De Backer D; Eurotherm3235Trial collaborators. European society of intensive care medicine study of therapeutic hypothermia (32-35°C) for intracranial pressure reduction after traumatic brain injury (the Eurotherm3235Trial). Trials 2011; 12:8.

 

Polderman KH. Therapeutic Temperature Management: State of the Art in the Critically ill:
Mechanisms of action, physiologic effects and complications of hypothermia. Critical Care Medicine 2009; 37:S186-202.

 

Polderman KH, Herold I. Therapeutic hypothermia and controlled normothermia in the ICU: practical considerations, side effects and cooling methods. Critical Care Medicine 2009; 37:1101-20

 

Van Zanten ARH, Polderman KH. Blowing hot and cold? Skin counterwarming to prevent shivering during therapeutic cooling. Critical Care Medicine 2009; 37:2106-8.

 

Weingart S, Mayer S, Polderman K. Rectal probe temperature lag during rapid saline induction of hypothermia after resuscitation from cardiac arrest. Resuscitation 2009; 80:837-8.

 

Polderman KH. Therapeutic cooling. In: Oxford Desk Reference Book: Critical Care, 1ST Edition. Waldmann C, Soni N, Rhodes A, Editors; Oxford University Press 2008; 60-61.

 

Polderman KH. Controversies in Intensive Care: Induced Hypothermia to treat neurological injuries. In: European Society of Intensive Care Medicine Yearbook 2008. Kuhlen R, Moreno R, Ranieri M, Rhodes A, editors; Springer Verlag, Berlin 2008; 257-66.

 

Polderman KH. Induced hypothermia and fever control for prevention and treatment of neurological injuries.
Lancet 2008; 371: 1955-69 (Review).

 

Polderman KH, Mayer SA, Menon D. Hypothermia therapy after traumatic brain injury in children. New England Journal Medicine 2008; 359:1178.

 

Polderman KH. Controversies in Intensive Care: Induced Hypothermia to treat neurological injuries. In: European Society of Intensive Care Medicine Yearbook 2008. Kuhlen R, Moreno R, Ranieri M, Rhodes A, editors; Springer Verlag, Berlin 2008.

 

Polderman KH. Induced hypothermia and fever control for prevention and treatment of neurological injuries. Lancet 2008; 371:1955-69 (Review).

 

Polderman KH, Menon DK, Girbes AR. Treating intracranial hypertension in traumatic brain injury: keep it cool! Intensive Care Medicine 2008; 34:1738-9.

 

Polderman KH. Hypothermia and neurological outcome after cardiac arrest: state of the art. European Journal of Anaesthesiology 2008; 42:23-30.

 

Andrews PJ, Citerio G, Longhi L, Polderman K, Sahuquillo J, Vajkoczy P; Neuro-Intensive Care and Emergency Medicine (NICEM) Section of the European Society of Intensive Care Medicine. NICEM consensus on neurological monitoring in acute neurological disease. Intensive Care Medicine 2008; 34:1362-70.

 

Polderman KH. Induced Hypothermia & Neurological Outcome: The 1ST Therapeutic Temperature Management Congress. ICU Management 2008; 4:46-47.

 

Polderman KH. Cardiac problems in Intensive Care Medicine: Cardiac arrest. In: European Society of Intensive Care Medicine: 25 years of progress and innovation. Kuhlen R, Moreno R, Ranieri M, Rhodes A (eds), Springer Verlag, Berlin 2007; 247-256.

 

Polderman KH. Induced Hypothermia and Fever Control in Neurological Injury: Cost-effectiveness Issues. ICU Management 2007; 3:14-16.

 

Polderman KH. Mechanisms and potential side effects of therapeutic mild hypothermia. In: Cardiac arrest: the science and practice of resuscitation medicine, 2ND edition; Paradis N, Halperin H, Kern K, Wenzel V, Chamberlain D, editors; Cambridge University Press 2007; 859-70.

 

Polderman KH. Inducing hypothermia: cost-effectiveness issues. ICU management 2007;3:14-16.

 

Polderman KH. Temperature management in critically ill patients: a call to arms. International Journal of Intensive Care, Spring 2007.

 

Polderman KH, Girbes ARJ. Hypothermia for neonates with hypoxic-ischemic encephalopathy. [Letter]. New England Journal of Medicine 2006; 354:1643-5.

 

Polderman KH. Induced hypothermia for neuroprotection: understanding the underlying mechanisms. In: 2006 yearbook of Intensive Care and Emergency Medicine, pp 337-351.

 

Polderman KH, Rijnsburger ER, Peerdeman SM, Girbes ARJ. Induction of hypothermia using large volumes of ice-cold intravenous fluid. Critical Care Medicine 2005; 33:2744-51.

 

Van Zanten ARH, Polderman KH. Early induction of hypothermia: will sooner be better? (Editorial). Critical Care Medicine 2005; 33:1449-52.


Polderman KH. Inducing hypothermia in the ICU: practical aspects and cooling methods. In: 2005 yearbook of Intensive Care and Emergency Medicine, pp 661-71.

 

Brux A, Girbes AR, Polderman KH. Controlled mild-to-moderate hypothermia in the intensive care unit. Anaesthesist 2005; 54:225-44 (Review).

 

Polderman KH. Keeping a cool head: how to induce and maintain hypothermia (Editorial). Critical Care Medicine 2004; 32:2558-60.

 

Hartemink KJ, Wisselink W, Rauwerda JA, Girbes AR, Polderman KH. Novel applications of therapeutic hypothermia: report of three cases. Critical Care 2004;8:R343-6.

 

Polderman KH, Ware JH. Therapeutic hypothermia following cardiac arrest: class I evidence? [Letter]. Intensive Care Medicine 2004; 30:2287.

 

Polderman KH. Therapeutic hypothermia in the Intensive Care unit: problems, pitfalls and opportunities (review). Part 1: indications and evidence. Intensive Care Medicine 2004; 30:556-75.

 

Polderman KH. Therapeutic hypothermia in the Intensive Care unit: problems, pitfalls and opportunities (review). Part 2: practical aspects and side effects. Intensive Care Medicine 2004; 30:757-69.

 

Polderman KH. Induced hypothermia to treat post-ischemic and post-traumatic injury. Scand J Trauma Resusc Emerg Med 2004; 12:5-20.

 

Polderman KH, Van Zanten ARH, Nipshagen MD, Girbes ARJ. Induced hypothermia in traumatic brain injury: effective if properly employed [Letter]. Critical Care Medicine 2004; 32:313-4.

 

Polderman KH. Use of induced hypothermia for neuroprotection. In: 2004 yearbook of Intensive Care and Emergency Medicine 830-43.


ILCOR:International Liasion Committee on Resuscitation(国際蘇生連絡協議会)

 

RCT:Randomized Controlled Traial(ランダム化比較試験)

 

Eurotherm 3235Trial:http://www.eurotherm3235trial.eu/home/index.phtml

(2012年8月更新)

 

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